TRANSMUCOSAL DRUG DELIVERY EBOOK DOWNLOAD!
The transmucosal route includes oral, nasal, vaginal, and urethral and presents a challenge in the field of novel drug delivery technology. Advances in transmucosal drug delivery. 1. Evaluatory seminar on Advances in oral trans mucosal drug delivery Presented by: Gasper. Int J Pharm. Aug 25; doi: /m Epub May Oral transmucosal drug delivery--current status and future.
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However, the absorption of an oral transmucosal drug delivery is usually too slowly to treat a BTP typical episode. For example, oral tablets of morphine, with an onset of action of 20 - 30 minutes [ 6 ], cannot be fast enough to provide treatment for BTP episode.
Transmucosal Drug Delivery- An Overview | BenthamScience
For that transmucosal drug delivery, pain management therapy that could be matching the fast onset of BTP continues to be a challenge. Generally, transmucosal drug delivery through intranasal or sublingual mucosa has been an area of great interest for systemic and central drug delivery resulting in fast onset of action [ 7 - 10 ].
It avoids the hepatic first-pass clearance and has a rapid onset of drug action. Note that the route of administration transmucosal drug delivery an important factor to consider in treatment of fast-onset condition such as BTP.
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It was reported that patients who administered short-acting opioid had an average time to transmucosal drug delivery relief as 31 range 5—75 minutes. No difference was found between oral short-acting opioids, while oral transmucosal fentanyl citrate worked faster than oral morphine, oxycodone, hydromorphone, and methadone [ 11 ].
Transmucosal drug delivery of lipophilic opioids has received a great attention due to their quick absorption and fast onset of pain management. Transmucosal administration of lipophilic opioids such as fentanyl revealed a great improvement in BTP management through the fastonset of action reported.
Currently, for transmucosal drug delivery treatment of BTP, fentanyl is marketed in the form of an injectable dosage form, which has always suffered from issues of patient compliance.
This is surprising in view of the advantages associated with OTDD, compared with conventional oral drug delivery. This review examines a number of aspects related to OTDD including the anatomy of the oral cavity, models currently used to study OTDD, as well as commercially available formulations and transmucosal drug delivery technologies.
Advances in oral transmucosal drug delivery.
The understanding of drug transport across tissues has increased. The administration of drug by transmucosal routes offers the advantage of being a relatively painless transmucosal drug delivery and has the potential for greater flexibility in a variety of clinical situations.
The transmucosal route includes oral, nasal, vaginal, and urethral and presents a challenge in the field of novel drug delivery technology.